Week 1 NFL predictions, odds, top picks from a reliable model: A potential five-team football parlay offering 25-1 payout
The NFL season is just around the corner, and with it comes a host of exciting matchups and unexpected odds.
In the 2024 season, Joe Burrow had a near-MVP year for the Cincinnati Bengals, leading them to promising performances. However, the team failed to make the playoffs, a disappointment for the talented quarterback. Fast forward to the 2025 season, and Burrow's Bengals will open against the Cleveland Browns, who have named Joe Flacco their Week 1 starter.
Meanwhile, the defending Super Bowl champion Philadelphia Eagles are aiming to win the NFC East in back-to-back years. They will face the Dallas Cowboys in the 2025 NFL Kickoff Game, a highly anticipated clash. The Eagles are favored in this matchup, but among outsiders, the Detroit Lions have relatively favorable odds, with 10.00 betting odds for the season winner.
The Washington Commanders, who reached the NFC Championship Game in the 2024 season, are another team to watch. Jayden Daniels, now in his second season, was dominant last year, and the Commanders won both meetings against the New York Giants. In Week 1 of the 2025 season, the Commanders are favored (-6, 45) against the Giants.
A computer model has scoured the Week 1 NFL odds and locked in five confident NFL best bets. The model is on an impressive 31-15 run on top-rated picks and has identified four other NFL matchups where it says the line is way off. Successfully parlaying the model's sports betting picks could result in a payout of nearly 25-1.
Interestingly, the model is backing an underdog that it says will not only cover, but win outright in Week 1. In simulated games, the model has the Commanders covering in over 60% of simulations against the Giants. The Commanders defeated the Giants in both meetings in the 2024 season, and the model predicts a similar outcome for Week 1.
The model's Week 1 NFL picks and parlay can be found on its website. For football fans, the 2025 season is shaping up to be an exciting one, filled with unexpected twists and turns. Stay tuned for more updates as the season unfolds.
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